Bryan J González, PhD

  • Instructor of Biochemistry at the Columbia University Medical Center

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Overview

Bryan J. González, PhD, is the Course Director of Biochemistry at the Institute of Human Nutrition at Columbia University. He received his MSc in Medical Biology from the University of Lausanne and his PhD in Nutritional and Metabolic Biology from Columbia University. As a faculty member in the IHN MS program, Dr. Gonzalez teaches courses on Biochemistry.

Academic Appointments

  • Instructor of Biochemistry at the Columbia University Medical Center

Administrative Titles

  • Course Director for the Institute of Human Nutrition (IHN)

Languages

  • French
  • Guarani
  • Spanish

Credentials & Experience

Education & Training

  • MSc, 2013 Medical Biology, University of Lausanne, Switzerland
  • PhD, 2019 Nutritional and Metabolic Biology, Columbia University

Research

Dr. González's doctoral and post-doctoral research in Dr. Egli’s and Dr. Leibel’s lab focused on the genetics of diabetes and using stem cells for tissue engineering and regenerative medicine. He is currently the Principal Scientist at Fork and Good, where his research group focuses on developing cell lines through gene editing to make cultivated meat for a sustainable future.

Selected Publications

  1. González BJ., Zhao H., Lee J., LeDuc CA., Goulbourne CN., Chen X., Chung WK., Jurczyk A., Gromada J., Shen Y., Goland RS., Leibel RL., Egli D., Reduced calcium levels and accumulation of abnormal insulin granules in stem cell models of HNF1A deficiency. Communications Biology. 2022.
  2. González BJ., Creusot R., Sykes M., Egli D., How Safe are Universal Stem Cells?. Cell Stem Cell. 2020.
  3. Ackeifi C., Wang P., Karakose E., Manning Fox JE., González BJ., Liu H., Wilson J., Swartz E., Berrouet C., Li Y., Kumar K., MacDonald PE., Sanchez R., Thorens B., DeVita R., Homann D., Egli D., Scott DK., Garcia-Ocana A., Stewart AF., GLP-1 receptor agonists synergize with DYRK1A inhibitors to potentiate functional human beta cell regeneration. Science Translational Medicine. 2020.
  4. Kuo T., Damle M., González BJ., Egli D., Lazar MA., Accili D., Induction of a cell-restricted Gc in dedifferentiating β cells contribute to stress-induced β cell dysfunction. JCI Insight. 2019.
  5. Wang P., Karakose E., Liu H., Swartz E., Ackeifi C., Zlatanic V., Wilson J., González BJ., Bender A., Takane KK., Ye L., Harb G., Pagliuca F., Homann D., Egli D., Argmann C., Scott DK., Garcia-Ocana A., Stewart AF., Combined Inhibition of DYRK1A, SMAD, and Trithorax Pathways Synergizes to Induce Robust Replication in Adult Human Beta Cells. Cell Metabolism. 2019.
  6. Guay C., Kruit JK., Rome S., Menoud V., Mulder NL., Jurdzinski A., Mancarella F., Sebastiani C., Donda A., González BJ., Jandus C., Bouzakri K., Pinget M., Boitard C., Romero P., Dotta F., Regazzi R., Lymphocyte-Derived Exosomal MicroRNAs Promote Pancreatic β Cell Death and May Contribute to Type 1 Diabetes Development. Cell Metabolism. 2019.
  7. Manterola M., Brown TM., Oh MY., Garyn C., González BJ., Wolgemuth DJ., BRDT is an essential epigenetic regulator for proper chromatin organization, silencing of sex chromosomes and crossover formation in male meiosis. PLoS Genetics. 2018.

For a complete list of publications, please visit PubMed.gov