The Karsenty laboratory uses genetics, cellular, molecular and clinical physiological approaches to pursue several fundamental questions of bone biology.
The purpose of the research in the Kousteni laboratory is to understand the influence of the skeleton on various physiological processes and in disease.
The Mendelsohn lab focuses on identification and characterization of progenitors that are important for development and regeneration of the urothelium, a water-proof barrier that lines the urinary outflow tract.
The Reilly Group at the Columbia University Irving Medical Center is dedicated to translational and genomic studies of human cardiometabolic disorders.
The Schwabe lab research seeks to elucidate mechanisms by which fibrosis and cancer develop in the chronically injured liver using mouse models, patient samples as well as novel Systems Biology approaches
Dr. Tsang's genome engineering laboratory is engaged in tackling neurodegenerative disorders by pursuing investigations in three areas, two of which include patient-specific mouse models: probing the role of phosphodiesterase (PDE) signaling in neurodegeneration, developing stem cell-based therapies for photoreceptor degeneration, and correlating the genotypes of various human retinal degenerations with the phenotypes revealed in live metabolic imaging (autofluorescence).
Dr. Wang's lab has worked for many years on the role of inflammation in modulating stem cells and promoting gastrointestinal neoplasia using mouse models.
Dr. Accili's research has delved into the pathogenesis of diabetes, the integrated physiology of insulin action and mechanisms of pancreatic beta dysfunction.
The Chung lab contributions have been in the discovery of new genes for human diseases and characterization of the mutation spectrum and molecular mechanism of disease, clinical characterization of the disorders associated with these gene mutations, and integration of these discoveries into clinical practice through the development and implementation of clinical genetic testing in medical care.
Dr. Diano’s research focuses on intracellular nutrient sensing mechanisms in brain cells regulating energy and glucose metabolism, and how their derangement promotes development of metabolic disorders.
The Egli lab works to find the mechanisms that result in abnormal and failed human development in order to mprove the efficiency of fertility treatments, to reduce the burden of disease-causing genetic change, and increase the chances of parents to have a healthy child.
The goals of Dr. Haeusler's research are to understand the development of proatherogenic metabolic abnormalities in insulin resistant individuals, and to identify new therapeutic targets for improving these abnormalities.
Dr. Laferrère’s laboratory studies mechanisms and biomarkers linking obesity and type 2 diabetes and the effect of various weight loss interventions, including tome restricted eating, on glucose and lipid metabolism and body composition in humans.
From bench to bedside and back again, Dr. Pajvani's lab uses basic and translational research methods to uncouple obesity from its metabolic complications via the Notch signaling pathway.
Research in the Shaprio lab focuses mainly on the biology of cell adhesion, particularly as it relates to establishing synaptic connections between neurons, using the retina as the primary model system.
Dr. Shukla's research is focused on novel interventions for management of obesity and type 2 diabetes including behavior modification, pharmacotherapy and endoscopic/ bariatric procedures with a key focus on the physiological effects and therapeutic implications of nutrient sequence/food order.
Dr. St-Onge studies the impact of lifestyle, specifically sleep and diet, on cardio-metabolic risk factors, conducts innovative, cutting-edge clinical research combining her expertise on sleep, nutrition, and energy balance regulation to address questions relating to the role of circadian rhythms, including sleep duration and timing as well as meal timing and eating patterns, on cardio-metabolic risk.
Major areas of focus in the Sykes lab include hematopoietic cell transplantation, organ allograft tolerance induction, xenotransplantation tolerance and Type 1 diabetes.
Dr. Thaker's work is focused on understanding the molecular underpinnings of severe early childhood obesity, and its influence on the clinical manifestations.
Dr. Wardlaw has done clinical neuroendocrine research for over 25 years ranging from studies of normal pituitary physiology to the diagnosis and treatment of pituitary diseases, including prolactinomas, acromegaly, Cushing's disease and lymphocytic hypophysitis.
The Woo Baidal lab translates clinical and epidemiologic findings into early life interventions to eliminate racial/ethnic and socioeconomic disparities in childhood obesity and its co-morbidities, including nonalcoholic fatty liver disease (NAFLD).
Ms. Elazari's research through the Office of Work Life includes the development, implementation, and evaluation of nutrition, weight management, and other workplace wellness programs and initiatives for Columbia University faculty and staff.
Dr. Glendinning investigates how the brain uses input from sensory systems in the mouth and gut to determine (a) the chemical composition of foods, (b) whether we like or dislike a particular food, and (c) which metabolic responses should be activated (e.g., insulin release) so as to facilitate post-absorptive processing of the food.
Dr. Madra's research interests include impacts of postnatal stressors on feeding behaviors during adolescence, particularly related to anorexia nervosa, and the effects of early life stress on gut function, enteric nervous system development and gut brain interactions.
Dr. Shukla's research is focused on novel interventions for management of obesity and type 2 diabetes including behavior modification, pharmacotherapy and endoscopic/ bariatric procedures with a key focus on the physiological effects and therapeutic implications of nutrient sequence/food order.
Dr. St-Onge studies the impact of lifestyle, specifically sleep and diet, on cardio-metabolic risk factors, conducts innovative, cutting-edge clinical research combining her expertise on sleep, nutrition, and energy balance regulation to address questions relating to the role of circadian rhythms, including sleep duration and timing as well as meal timing and eating patterns, on cardio-metabolic risk.
The major focus of Christiano Lab research is the study of inherited skin and hair disorders in humans and mice, through a classical genetic approach including identification and phenotyping of disease families, genetic linkage, gene discovery and mutation analysis, and functional studies relating these findings to basic questions in epidermal biology.
Work in the Han lab is focused on Investigating the role of oral bacteria in extra-oral infection and inflammation, investigating the mechanisms of Fusobacterium nucleatum pathogenesis in pregnancy complications and colorectal cancer, and developing genetic tools for mutant construction in bacteria.
Dr. Madra's research interests include impacts of postnatal stressors on feeding behaviors during adolescence, particularly related to anorexia nervosa, and the effects of early life stress on gut function, enteric nervous system development and gut brain interactions.
Major areas of focus in the Sykes lab include hematopoietic cell transplantation, organ allograft tolerance induction, xenotransplantation tolerance and Type 1 diabetes.
The Bauer Lab uses a mix of molecular biology, animal physiology, and functional genomics to translate human genetics studies into actionable biological mechanisms, with a specific focus on cardiometabolic traits.
The major focus of Dr. Deckelbaum’s laboratory is to determine regulatory mechanisms for cell-lipid particle interaction, and cell cholesterol and triglyceride metabolism.
The Ginsberg lab conducts research related to the regulation of the levels and metabolism of apolipoprotein B-containing lipoproteins, the lipoproteins carrying triglycerides and the bulk of cholesterol in. These include the atherogenic very low density and low density lipoproteins.
The goals of Dr. Haeusler's research are to understand the development of proatherogenic metabolic abnormalities in insulin resistant individuals, and to identify new therapeutic targets for improving these abnormalities.
Dr. Laferrère’s laboratory studies mechanisms and biomarkers linking obesity and type 2 diabetes and the effect of various weight loss interventions, including tome restricted eating, on glucose and lipid metabolism and body composition in humans.
The Reilly Group at the Columbia University Irving Medical Center is dedicated to translational and genomic studies of human cardiometabolic disorders.
The Tabas laboratory studies the cellular biology of cardiometabolic disease, with an emphasis on the molecular-cellular mechanisms of advanced atherosclerosis and hepatic insulin resistance and NASH in obesity, and the links between these processes.
Dr. Zhang’s laboratory seeks to understand the dynamic role of macrophages in cardiometabolic diseases with the aim of finding novel mechanisms and new treatments.
Dr. Area Gomez's lab is currently researching how C99 contributes to the regulation of lipid homeostasis, and how the alteration in the level of C99 in MAMs plays a role in the pathogenesis of AD.
The major focus of Dr. Deckelbaum’s laboratory is to determine regulatory mechanisms for cell-lipid particle interaction, and cell cholesterol and triglyceride metabolism.
Dr. Diano’s research focuses on intracellular nutrient sensing mechanisms in brain cells regulating energy and glucose metabolism, and how their derangement promotes development of metabolic disorders.
Dr. Glendinning investigates how the brain uses input from sensory systems in the mouth and gut to determine (a) the chemical composition of foods, (b) whether we like or dislike a particular food, and (c) which metabolic responses should be activated (e.g., insulin release) so as to facilitate post-absorptive processing of the food.
The Owusu-Ansah lab is interested in elucidating the signaling mechanisms that regulate adaptive compensatory responses to mitochondrial distress; and how interfering with these responses impact muscle and neuronal function.
Dr. Laferrère studies mechanisms and biomarkers linking obesity and type 2 diabetes and the effect of various weight loss interventions on improved metabolism.
Dr. Pon's lab studies the mechanism underlying the processes described below, how they affect lifespan and change as yeast cells age, and whether modulation of those processes can extend lifespan.
The Tabas laboratory studies the cellular biology of cardiometabolic disease, with an emphasis on the molecular-cellular mechanisms of advanced atherosclerosis and hepatic insulin resistance and NASH in obesity, and the links between these processes.
Dr. Thomas has a research interest in using stable isotopes to understand impaired flux through metabolic pathways associated with acquired and inherited diseases.
Research in the Cardoso lab focuses on the regulation of lung development, regeneration-repair and the role of developmental signaling in adult lung diseases.
The major focus of Christiano Lab research is the study of inherited skin and hair disorders in humans and mice, through a classical genetic approach including identification and phenotyping of disease families, genetic linkage, gene discovery and mutation analysis, and functional studies relating these findings to basic questions in epidermal biology.
Dr. Gamble's research focuses on nutritional biochemistry at both basic and applied levels. Her earlier work on retinoid metabolism included studies on proteins involved in retinoid transport and in the generation of transcriptionally active retinoic acid metabolites.
The overall goal of research in the Greene laboratory is to understand the mechanisms whereby neuronal precursors differentiate into mature functional neurons.
The Mendelsohn lab focuses on identification and characterization of progenitors that are important for development and regeneration of the urothelium, a water-proof barrier that lines the urinary outflow tract.
Dr. Thaker's work is focused on understanding the molecular underpinnings of severe early childhood obesity, and its influence on the clinical manifestations.
Dr. Tsang's genome engineering laboratory is engaged in tackling neurodegenerative disorders by pursuing investigations in three areas, two of which include patient-specific mouse models: probing the role of phosphodiesterase (PDE) signaling in neurodegeneration, developing stem cell-based therapies for photoreceptor degeneration, and correlating the genotypes of various human retinal degenerations with the phenotypes revealed in live metabolic imaging (autofluorescence).
The research interests of the Wolgemuth lab focus on understanding the genetic control of gametogenesis and embryogenesis using mouse models and gene targeting, transgenic, and molecular and cell biological approaches.
Dr. Diano’s research focuses on intracellular nutrient sensing mechanisms in brain cells regulating energy and glucose metabolism, and how their derangement promotes development of metabolic disorders
Dr. Glendinning investigates how the brain uses input from sensory systems in the mouth and gut to determine (a) the chemical composition of foods, (b) whether we like or dislike a particular food, and (c) which metabolic responses should be activated (e.g., insulin release) so as to facilitate post-absorptive processing of the food.
The overall goal of research in the Greene laboratory is to understand the mechanisms whereby neuronal precursors differentiate into mature functional neurons.
Dr. Madra's research interests include impacts of postnatal stressors on feeding behaviors during adolescence, particularly related to anorexia nervosa, and the effects of early life stress on gut function, enteric nervous system development and gut brain interactions.
As a translational research laboratory studying the psychophysics and physiology of cognitive processes, the Sun lab uses eye tracking to diagnose neurological disease including progressive supranuclear palsy, cerebellar disease and other neurodegenerative diseases.
The major focus of Christiano Lab research is the study of inherited skin and hair disorders in humans and mice, through a classical genetic approach including identification and phenotyping of disease families, genetic linkage, gene discovery and mutation analysis, and functional studies relating these findings to basic questions in epidermal biology.
The Chung lab contributions have been in the discovery of new genes for human diseases and characterization of the mutation spectrum and molecular mechanism of disease, clinical characterization of the disorders associated with these gene mutations, and integration of these discoveries into clinical practice through the development and implementation of clinical genetic testing in medical care.
The Embree lab uses basic and pathological scientific findings to serve as the foundation and building blocks essential for developing regenerative medicinal strategies to treat musculoskeletal disease, such as temporomandibular disorders and osteoarthritis.
The Ginsberg lab conducts research related to the regulation of the levels and metabolism of apolipoprotein B-containing lipoproteins, the lipoproteins carrying triglycerides and the bulk of cholesterol in. These include the atherogenic very low density and low density lipoproteins.
Dr. Laferrère’s laboratory studies mechanisms and biomarkers linking obesity and type 2 diabetes and the effect of various weight loss interventions, including tome restricted eating, on glucose and lipid metabolism and body composition in humans.
The Reilly Group at the Columbia University Irving Medical Center is dedicated to translational and genomic studies of human cardiometabolic disorders.
The Tabas laboratory studies the cellular biology of cardiometabolic disease, with an emphasis on the molecular-cellular mechanisms of advanced atherosclerosis and hepatic insulin resistance and NASH in obesity, and the links between these processes.
Dr. Thaker's work is focused on understanding the molecular underpinnings of severe early childhood obesity, and its influence on the clinical manifestations.
Dr. Accili's research has delved into the pathogenesis of diabetes, the integrated physiology of insulin action and mechanisms of pancreatic beta dysfunction.
The Egli lab works to find the mechanisms that result in abnormal and failed human development in order to mprove the efficiency of fertility treatments, to reduce the burden of disease-causing genetic change, and increase the chances of parents to have a healthy child.
The Embree lab uses basic and pathological scientific findings to serve as the foundation and building blocks essential for developing regenerative medicinal strategies to treat musculoskeletal disease, such as temporomandibular disorders and osteoarthritis.
The Ginsberg lab conducts research related to the regulation of the levels and metabolism of apolipoprotein B-containing lipoproteins, the lipoproteins carrying triglycerides and the bulk of cholesterol in. These include the atherogenic very low density and low density lipoproteins.
The Mendelsohn lab focuses on identification and characterization of progenitors that are important for development and regeneration of the urothelium, a water-proof barrier that lines the urinary outflow tract.
Dr. Tsang's genome engineering laboratory is engaged in tackling neurodegenerative disorders by pursuing investigations in three areas, two of which include patient-specific mouse models: probing the role of phosphodiesterase (PDE) signaling in neurodegeneration, developing stem cell-based therapies for photoreceptor degeneration, and correlating the genotypes of various human retinal degenerations with the phenotypes revealed in live metabolic imaging (autofluorescence).
The research interests of the Wolgemuth lab focus on understanding the genetic control of gametogenesis and embryogenesis using mouse models and gene targeting, transgenic, and molecular and cell biological approaches.
