Lale Ozcan

  • Assistant Professor of Medical Sciences (in Medicine)
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Overview

Dr. Lale Ozcan received her medical degree from Istanbul University Cerrahpasa School of Medicine and did postdoctoral work at Harvard and Columbia Universities focusing on mechanisms linking metabolic stress with insulin resistance and type 2 diabetes. Her work focuses on exploring novel signaling pathways that control metabolic homeostasis.

Email: lo2192@cumc.columbia.edu

Academic Appointments

  • Assistant Professor of Medical Sciences (in Medicine)

Gender

  • Female

Credentials & Experience

Education & Training

  • Istanbul University Cerrahpasa School of Medicine, Turkey

Research

Current research in Ozcan Lab (http://laleozcanlab.com/) focuses on identification of novel mechanisms involved in obesity-induced insulin resistance, dyslipidemia, and their effects on atherosclerosis. We focus on the liver and other insulin-sensitive tissues, including adipose tissue, with an aim to bring new mechanistic insights into obesity-associated metabolic abnormalities and identify potential therapeutic targets.

Selected Publications

  1. Wang Y, Spolitu S, Zadroga JA, Sarecha AK, Ozcan L. Hepatocyte Rap1a contributes to obesity- and statin-associated hyperglycemia. Cell Reports 2022, 40(8):111259. PMID: 36001955, PMC9446800
  2. Dai W, Choubey M, Patel S, Singer HA, Ozcan L. Adipocyte CAMK2 deficiency improves obesity-associated glucose intolerance. Molecular Metabolism 2021, 53:1001300. PMID: 34303021, PMC8365526
  3. Spolitu S, Okamoto H, Dai W, Zadroga JA, Wittchen ES, Gromada J, Ozcan L. Hepatic glucagon signaling regulates PCSK9 and LDL-cholesterol. Circulation Res. 2019, 124:38-51. PMID: 30582457, PMC6457439
  4. Spolitu S, Dai W, Zadroga JA, Ozcan L. PCSK9 and Lipid Metabolism. Curr Opin Lipidol 2019, 3:186-191. PMID: 30925519, PMC6824479
  5. Ozcan L, Wong CCL, Li G, Xu T, Park SKR, Wronska A, Chen BX, Marks AR, Fukamizu A, Backs J, Singer HA, Yates JR III, Accili D, Tabas I.  Regulation of hepatic glucose production by a calcium-sensing enzyme, CaMKII. Cell Metab. 2012, 15, 1-13. PMID: 22503562, PMC3348356