Overview
Email: rah2130@columbia.edu
Laboratory website: Haeusler Lab
HAEUSLER LABAcademic Appointments
- Associate Professor of Pathology and Cell Biology
Credentials & Experience
Education & Training
- BS, 2000 Biology, Massachusetts Institute of Technology
- PhD, 2007 Biological Chemistry, University of Michigan
Research
Throughout the day, during and between meals, the body must continuously determine: (1) how much glucose, fat, and cholesterol should be generated or eliminated, and (2) how to transport those molecules between tissues and fluids. Our lab investigates how insulin signaling controls these processes, and how they become disrupted in conditions like insulin resistance, diabetes, liver disease, and atherosclerosis.
Welcome to Haeusler Lab.
Research Interests
- Metabolism
- Bile acids
- Cholesterol
- Lipids
- Glucose
- Insulin
- Diabetes
- Obesity
- Atherosclerosis
- Liver
- Gut
Selected Publications
- Izquierdo MC, Shanmugarajah N, Lee SX, Kraakman MJ, Westerterp M, Kitamoto T, Harris M, Cook JR, Gusarova GA, Zhong K, Marbuary E, O-Sullivan I, Rasmus NF, Camastra S, Unterman T, Ferrannini E, Hurwitz BE, Haeusler RA. (2022) Hepatic FoxOs link insulin signaling with plasma lipoprotein metabolism through an apolipoprotein M/sphingosine-1-phosphate pathway. J Clin Invest 132: e146219
- Oteng A-B, Higuchi S, Banks AS, Haeusler RA. (2021) Cyp2c-deficiency depletes muricholic acids and protects against high fat diet-induced obesity in male mice but promotes liver damage. Mol Metab 53: 101326
- Ahmad TR, Higuchi S, Bertaggia E, Hung A, Shanmugarajah N, Guilz NC, Gamarra JR, Haeusler RA. (2020) Bile acid composition regulates the manganese transporter Slc30a10 in intestine. J Biol Chem 295: 12545-12558
- Higuchi S, Ahmad TR, Argueta DA, Perez PA, Zhao C, Schwartz GJ, DiPatrizio NV, Haeusler RA. (2020) Bile acid composition regulates GPR119-dependent intestinal lipid sensing and food intake regulation in mice. Gut 69: 1620-1628
- Ahmad TR and Haeusler RA. (2019) Bile aci ds in glucose metabolism and insulin signaling: mechanisms and research needs Nat Rev Endocrinol 15: 701-712
- Lee SX, Heine M, Schlein C, Ramakrishnan R, Liu J, Belnavis G, Haimi I, Fischer AW, Ginsberg HN, Heeren J, Rinninger F, and Haeusler RA. (2018) FoxO Transcription Factors are Required for Hepatic HDL-Cholesterol Clearance J Clin Invest 128: 1615-1626
- Kim KJ, Goldberg IJ, Graham MJ, Sundaram M, Bertaggia E, Lee SX, Qiang L, Haeusler RA, Metzger D, Chambon P, Yao Z, Ginsberg HN, and Pajvani UB (2018) Gamma-secretase inhibition lowers plasma triglyceride-rich lipoproteins by stabilizing the LDL receptor Cell Metab 27: 816-827
- Bertaggia E, Jensen K, Castro-Perez J, Xu Y, Di Paolo G, Chan RB, Wang L, Haeusler RA. (2017) Cyp8b1 ablation prevents western diet-induced weight gain and hepatic steatosis due to impaired fat absorption. Am J Physiol Endocrinol Metab 313: E121-E133
For a complete list of publications, please visit PubMed.gov