Dr. Chang’s research is focused on understanding how bioactive lipid mediators, such as fish oil-derived omega-3 fatty acids, modulate innate immune cell biology, which is fundamental to the body’s basic responses to systemic inflammation linked to the pathogenesis of many inflammation-related diseases, including infection, tissue injury, metabolic disorder and cardiovascular disease (CVD). Her earlier findings described and established the mechanisms underlying the protective roles of dietary omega‐3 fats against atherosclerotic CVD by regulating plasma lipid profiles and improving systemic and focal aortic inflammatory responses in various experimental cell culture and rodent models.
Recent projects in Dr. Chang’s laboratory sought to ascertain the molecular mechanisms of the action of acute omega-3 fatty acid treatment on improving systemic inflammation with respect to membrane microstructure. Assessing metabolic characteristics and tissue fatty acid enrichment of a novel emulsion compound containing medium-chain triglycerides (MCT) and fish oil that may cooperatively modulate membrane lipid composition and cellular lipid metabolism to achieve the fastest and highest-magnitude anti-inflammatory effects is a current focus of her laboratory. These studies will yield novel information on the optimal composition of omega-3-containing lipid particles that maximizes cellular enrichment of omega-3 fatty acids, ultimately informing the design of potential therapeutic agents for systemic inflammation related to acute infection, traumatic injury, and tissue remodeling.
For more information, please contact Dr. Chuchun Liz Chang at email@example.com or call her lab at (212) 304-7939. The Chang lab is located at BB459-460 in Black Building, 4th floor.
Hu C, Zhuang, Q, Carpentier AC, Deckelbaum RJ, Chang CL. “Blood clearance kinetics and organ delivery of medium-chain triglyceride and fish oil-containing lipid emulsions: comparing different animal animal species”. Clin Nutr. 2020 Jul 14:S0261-5614(20)30344-7. PMID: 32753350.
Zirpoli H, Chang CL, Michael-Titus A, Carpentier YA, Ten VS, Deckelbaum RJ. ” Novel approaches for omega-3 fatty acid therapeutics: chronic versus acute administration to protect heart, brain and spinal cord”. Annu Rev Nutr. 2020 Sep 23;40:161-187. PubMed PMID: 32966188.
Kollareth Manual DJ, Chang CL, Zirpoli J, Deckelbaum RJ. “Molecular mechanisms underlying effects of n-3 and n-6 fatty acids in cardiovascular diseases”. Lipid signaling and metabolism. Elsevier. 2020: pp. 427–453
Chang CL. “Lipoprotein lipase: New roles for an "old" enzyme". Curr Opin Clin Nutri Metab Care. 2019 Mar;22(2):111-115. PMID: 30648986
Chang CL, Garcia-Arcos I, Nyrén R, Olivecrona G, Kim JY, Hu Y, Agrawal RA, Murphy AJ, Goldberg IJ, Deckelbaum RJ. “Lipoprotein lipase deficiency impairs bone marrow myelopoiesis and reduces circulating monocyte levels”. Arterioscler Thromb Vasc Biol. 2018 Mar;38(3):509-519. PMID:29371243
Kollareth Manual DJ, Chang CL, Hansen IH, Deckelbaum RJ. “Radiolabeled cholesteryl ethers: a need to analyze for biological stability before use”. Biochem Biophys Rep. 2017 Nov 16;13:1-6. PMID: 29188234
Chang CL, Torrejon C, Jung UJ, Graf K, Deckelbaum RJ. “ Incremental replacement of saturated fats by n-3 fatty acids in high-fat, high-cholesterol diets reduces elevated plasma lipid levels and arterial lipoprotein lipase, macrophages and atherosclerosis in LDLR-/- mice“. Atherosclerosis. 2014 Apr 3;234(2):401-409. PMID: 24747115.
Jung UJ, Torrejon C, Chang CL, Hamai H, Worgall TS, Deckelbaum RJ. “Fatty acids regulate endothelial lipase and inflammatory markers in macrophages and in mouse aorta: a role for PPARγ”. Arterioscler Thromb Vasc Biol. 2012 Dec;32(12):2929-37. PMID:23042820.